Journal article
Assembly of Bioactive Nanoparticles via Metal-Phenolic Complexation
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Zhixing Lin, Yijiao Qu, Agata Glab, Yiyuan Han, Joseph J Richardson, Frank Caruso
Advanced Materials | Wiley | Published : 2022
Abstract
The integration of bioactive materials (e.g., proteins and genes) into nanoparticles holds promise in fields ranging from catalysis to biomedicine. However, it is challenging to develop a simple and broadly applicable nanoparticle platform that can readily incorporate distinct biomacromolecules without affecting their intrinsic activity. Herein, a metal-phenolic assembly approach is presented whereby diverse functional nanoparticles can be readily assembled in water by combining various synthetic and natural building blocks, including poly(ethylene glycol), phenolic ligands, metal ions, and bioactive macromolecules. The assembly process is primarily mediated by metal-phenolic complexes throu..
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Grants
Awarded by Australian Research Council Discovery Project
Awarded by National Health and Medical Research Council Senior Principal Research Fellowship
Funding Acknowledgements
This research was conducted and funded by an Australian Research Council Discovery Project (DP200100713). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP), Biosciences Microscopy Unit at The University of Melbourne, and the Victorian Node of the Australian National Fabrication Facility (ANFF). Transmission electron microscopy and energy-dispersive X-ray spectroscopy experiments were conducted at the Bio21 Advanced Microscopy Facility, The University of Melbourne. The authors acknowledge Dr. Sukhvir Kaur Bhangu, Dr. Chan-Jin Kim, Dr. Yingjie Hu, Shiyao Li, and Wanjun Xu for helpful discussions.